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Age-related differences in olfactory cleft volume in adults: A computational volumetric study
Mitchell L Worley1, Rodney J Schlosser1, Zachary M Soler1
1Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, U.S.A.
The Laryngoscope
|October 18, 2018
Summary
Olfactory cleft (OC) volume increases with age, alongside changes in nasal sinus anatomy. This finding is crucial for understanding age-related olfactory dysfunction in older adults.
Area of Science:
- Gerontology
- Neuroscience
- Anatomy
Background:
- Olfactory dysfunction is a growing concern with an aging global population.
- Olfactory cleft (OC) volume is critical for odorant deposition and olfactory function.
- Age-related changes in OC volume are not well understood.
Purpose of the Study:
- To investigate age-related variations in OC volume using automated techniques.
- To determine the spatial specificity of age-related effects on OC volume.
- To correlate OC volume changes with sinonasal anatomy in aging adults.
Main Methods:
- Retrospective cross-sectional study design.
- Deformation-based morphometry applied to T1-weighted MRI scans.
- Analysis of two independent adult samples (MUSC and Hammersmith).
Main Results:
- Significant positive association found between age and OC volume in both samples.
- Age-related increases in OC volume occurred consistently across the lifespan.
- OC volume increases were associated with decreased sinus volumes and increased non-OC nasal cavity volumes.
Conclusions:
- Increasing age is associated with increased OC volume within the context of broader age-related sinonasal anatomical changes.
- Further research is needed to explore the impact of these anatomical changes on nasal airflow, odorant deposition, and olfactory function.
- Findings contribute to understanding the mechanisms of age-related olfactory dysfunction.
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