Related Experiment Video
Updated: Feb 3, 2026

Studying Normal Tissue Radiation Effects using Extracellular Matrix Hydrogels
Published on: July 24, 2019
A novel vertebrate system for the examination and direct comparison of the relative biological effectiveness for
E R Szabó1, Z Reisz2, R Polanek1
1a Extreme Light Infrastructure - Attosecond Light Pulse Source, ELI-HU Non-Profit Ltd , Szeged , Hungary.
Purpose:
The recent rapid increase of hadron therapy applications requires the development of high performance, reliable in vivo models for preclinical research on the biological effects of high linear energy transfer (LET) particle radiation.
Aim:
The aim of this paper was to test the relative biological effectiveness (RBE) of the zebrafish embryo system at two neutron facilities.
Material And Methods:
Series of viable zebrafish embryos at 24-hour post-fertilization (hpf) were exposed to single fraction, whole-body, photon and neutron (reactor fission neutrons (
Results:
The higher energy of the fast neutron beams represents lower RBE (ref. source LINAC 6 MV photon). The lethality rate in the zebrafish embryo model was 10 times higher for 1 MeV fission neutrons and 2.5 times greater for p (18 MeV)+Be cyclotron generated fast neutron beam when compared to photon irradiation results. Dose-dependent organ perturbations (shortening of the body length, spine curvature, microcephaly, micro-ophthalmia, pericardial edema and inhibition of yolk sac resorption) and microscopic (marked cellular changes in eyes, brain, liver, muscle and the gastrointestinal system) changes scale together with the dose response.
Conclusion:
The zebrafish embryo system is a powerful and versatile model for assessing the effect of ionizing radiation with different LET values on viability, organ and tissue development.
More Related Videos
Related Concept Videos
Biological Effects of Radiation
Sources of Self-Esteem III: Social Comparison
Atomic Absorption Spectroscopy: Radiation and Light Sources
Two common narrow-range 'line' sources used in AAS are hollow-cathode lamps (HCLs) and...
The Sense of Self: Reflected Self-Appraisal and Social Comparison
Directing and Steric Effects in Disubstituted Benzene Derivatives
Muscles of the Vertebral Column
Superficial Layer:
The superficial layer consists primarily of the splenius muscles, which include the splenius capitis and splenius cervicis. These muscles are mainly responsible for the head and cervical spine movements, including extension, rotation, and lateral bending. The splenius capitis...

