Related Experiment Video

Updated: Feb 3, 2026

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS
07:33

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS

Published on: December 21, 2011

16.0K

Taurine attenuates OTA-promoted PCV2 replication through blocking ROS-dependent autophagy via inhibiting AMPK/mTOR

Nianhui Zhai1, Hong Wang1, Ying Chen1

  • 1College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China.

Chemico-Biological Interactions
|October 18, 2018
PubMed

Insights

Taurine inhibits ochratoxin A-induced PCV2 replication by blocking autophagy via the ROS/AMPK/mTOR pathway. This study supports taurine as a potential intervention for PCV2 infections.

Area of Science:

  • Veterinary Virology
  • Toxicology
  • Cellular Biology

Background:

  • Ochratoxin A (OTA) promotes Porcine circovirus type 2 (PCV2) replication by inducing autophagy.
  • Understanding the mechanisms behind OTA's effects is crucial for developing interventions.

Purpose of the Study:

  • To evaluate the effect of taurine on OTA-promoted PCV2 replication.
  • To elucidate the underlying molecular mechanisms of taurine's action.

Main Methods:

  • In vitro study using PK-15 cells.
  • Assessment of PCV2 replication, reactive oxygen species (ROS) levels, and autophagy.
  • Analysis of the AMPK/mTOR signaling pathway.

Main Results:

  • Taurine inhibited OTA-induced PCV2 replication in PK-15 cells.
  • Taurine attenuated ROS levels and blocked OTA-induced autophagy.
  • Taurine regulated the ROS/AMPK/mTOR signaling axis, suppressing autophagy.

Conclusions:

  • Taurine suppresses autophagy by modulating the ROS/AMPK/mTOR pathway, thereby inhibiting OTA-promoted PCV2 replication.
  • Taurine shows promise as a dietary intervention against PCV2 infection.
Keywords:
5ʹAMP-activated protein kinaseAutophagyOchratoxin APorcine circovirus type 2Taurine

More Related Videos

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

15.9K
Activating Autophagy by Aerobic Exercise in Mice08:44

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

12.7K

Related Concept Videos

PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
5.6K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
10.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.8K
Contact-dependent Signaling01:19

Contact-dependent Signaling

Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
47.0K
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.6K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.1K