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Continuous glucose monitoring use and glucose variability in pre-school children with type 1 diabetes

Klemen Dovc1, Kevin Cargnelutti2, Anze Sturm3

  • 1Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital, University Medical Centre, Ljubljana, Slovenia; Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

Diabetes Research and Clinical Practice
|October 18, 2018
PubMed

Insights

Continuous glucose monitoring (CGM) use in preschoolers with type 1 diabetes significantly reduced glucose variability over five years. This technology is associated with better glucose control in young children.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Diabetes Management

Background:

  • Type 1 diabetes (T1D) management in pre-schoolers presents unique challenges.
  • Glucose variability is a key factor in T1D complications.
  • Continuous Glucose Monitoring (CGM) offers potential for improved management.

Purpose of the Study:

  • To evaluate the correlation between CGM use and glucose variability in pre-schoolers with T1D.
  • To assess the impact of CGM on glycemic control in this age group.
  • To analyze CGM data over a 5-year follow-up period.

Main Methods:

  • Nationwide population-based cohort study utilizing the Slovenian National Registry.
  • Analysis of glucose variability during periods with and without CGM use over 5 years.
  • Inclusion of 40 children under 8 years old, with a mean age of 3.5 years at CGM initiation.

Main Results:

  • CGM use was associated with a significant reduction in the standard deviation of mean glucose (3.6 mmol/L with CGM vs. 4.3 mmol/L without, p < 0.001).
  • Coefficient of variation for glucose was also lower with CGM use (44.0% vs. 46.1%, p = 0.021).
  • Frequent CGM use (>5 days/week) correlated with a 0.4% reduction in glycated hemoglobin (HbA1c).

Conclusions:

  • CGM use is linked to reduced glucose variability in pre-schoolers with type 1 diabetes.
  • The findings support the integration of CGM for improved diabetes management in young children.
  • Further research can explore long-term outcomes and optimal CGM utilization strategies.
Abstract

Keywords:
ChildrenContinuous glucose monitoringInsulin therapyType 1 Diabetes

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