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[Postoperative abnormal liver function in children with heart surgery].

Lian Duan1, Guohuang Hu2, Meng Jiang1

  • 1Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
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Summary
This summary is machine-generated.

Abnormal liver function tests are common after pediatric heart surgery, affecting 30% of patients. Prolonged mechanical ventilation is a key independent risk factor for these adverse liver outcomes.

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Area of Science:

  • Pediatric Cardiology
  • Hepatology
  • Surgical Outcomes Research

Background:

  • Postoperative abnormal liver function tests (aLFT) are a concern in pediatric cardiac surgery.
  • Understanding the incidence and risk factors for aLFT is crucial for improving patient outcomes.

Purpose of the Study:

  • To determine the incidence of aLFT in children undergoing heart surgery.
  • To identify clinical characteristics and risk factors associated with aLFT in this population.

Main Methods:

  • A cohort of 143 children (<18 years) undergoing heart surgery in 2017 was studied.
  • Liver function tests were monitored preoperatively and for five days postoperatively.
  • Clinical data and risk factors for aLFT were analyzed using logistic regression.

Main Results:

  • 30% (43/143) of patients experienced aLFT, with 3.5% (5/143) developing acute liver injury.
  • aLFT occurred most frequently on postoperative day one (51.2%).
  • Risk factors included higher Risk Adjustment for Congenital Heart Surgery-1 (RACHS-1) score, cyanosis, longer cardiopulmonary bypass time, elevated cardiac troponin I (cTnI), higher inotropic score (IS), more transfusions, and longer mechanical ventilation time.

Conclusions:

  • Abnormal liver function tests are common following pediatric heart surgery and can lead to poor outcomes.
  • Mechanical ventilation time emerged as an independent risk factor for developing aLFT.