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Updated: Feb 3, 2026
06:50
Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia
Published on: March 20, 2018
12.9K
Anesthesia protocols in laboratory animals used for scientific purposes
Luca Cicero1, Salvatore Fazzotta, Vincenzo Davide Palumbo
1Istituto Zooprofilattico Sperimentale della Sicilia "A. Mirri" Palermo. cicero.luca@libero.it.
Acta Bio-Medica : Atenei Parmensis
|October 19, 2018
Summary
Selecting the right anesthesia protocol is crucial for reliable animal research. This review examines anesthesia induction methods for common laboratory animals to improve experimental consistency.
Area of Science:
- Veterinary Anesthesiology
- Laboratory Animal Science
- Experimental Research Methodology
Background:
- Anesthesia protocols significantly impact experimental outcomes in animal models.
- A universally accepted anesthesia protocol for induction, maintenance, and recovery is lacking.
- Endotracheal intubation with inhalation anesthesia is common in large animals but technically challenging for small animals.
Purpose of the Study:
- To review the primary methods for inducing anesthesia in laboratory animals.
- To provide insights into anesthesia techniques for diverse experimental settings.
Main Methods:
- Conducted an electronic literature search of PubMed, ISI Web of Science, and Scopus.
- Keywords included "anesthesia", "animal(s)", "protocol(s)", and "surgery".
- Focused on common laboratory animals (rats, mice, rabbits, pigs) across various research areas (surgery, CT, MRI, PET).
Main Results:
- Identified and reviewed scientific articles detailing anesthesia induction in laboratory animals.
- Highlighted the technical considerations for anesthesia in different animal sizes.
- Synthesized information on anesthesia practices in experimental surgery and imaging.
Conclusions:
- Emphasizes the need for standardized anesthesia guidelines in animal research.
- Recommends reporting specific anesthesia and euthanasia protocols to enhance study comparability and quality.
- Aims to improve the reliability and reproducibility of animal experiments through better anesthetic practices.
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