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Could decorin be a biomarker of coronary artery disease? A pilot study in human beings

Saeed Nazemi1, Atefeh Rezapour, Seyed Mohammad Hassan Moallem

  • 1Department of Cardiovascular Diseases, Razavi Hospital, Iran;. saeednazemi@gmail.com.

Acta Bio-Medica : Atenei Parmensis
|October 19, 2018
PubMed

Insights

Decorin (DCN) serum concentration was not found to correlate with coronary artery calcification (CAC) in patients with coronary artery disease. This suggests DCN is not a reliable biomarker for assessing cardiovascular event risk.

Area of Science:

  • Cardiovascular research
  • Biomarker discovery
  • Atherosclerosis research

Background:

  • Identifying patients at risk for cardiovascular events is crucial.
  • Coronary artery calcification (CAC) assesses cardiovascular risk in intermediate-risk individuals.
  • Decorin (DCN) is implicated in arterial calcification and atherosclerotic plaque.

Purpose of the Study:

  • To investigate the correlation between serum Decorin (DCN) concentration and Coronary Artery Calcification (CAC) in humans.
  • To evaluate DCN as a potential biomarker for cardiovascular disease risk.

Main Methods:

  • 84 patients with coronary artery disease were included.
  • Demographic data and cardiovascular risk factors were collected.
  • CT-Angiography determined CAC scores; ELISA measured DCN serum levels.

Main Results:

  • No significant correlation was observed between DCN serum concentration and total CAC score.
  • DCN levels did not correlate with CAC in specific coronary arteries (LAD, RCA, LM, Cx).

Conclusions:

  • Serum Decorin (DCN) concentration does not appear to be a suitable biomarker for coronary artery disease.
  • Further research with larger sample sizes is needed to confirm these findings.
Abstract

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