Face Rejuvenation: a new combinated protocol for biorevitalization.

Area of Science:

• Dermatology
• Aesthetic Medicine
• Anti-aging Research

Background:

• Facial aging is a complex process attracting significant research interest.
• Biorevitalization and skin rejuvenation are key areas of focus.
• Mesotherapy, hyaluronic acid, and carbon dioxide injections are explored for anti-aging effects.

Purpose of the Study:

• To evaluate the efficacy of mesotherapy with hyaluronic acid and carbon dioxide injections for facial rejuvenation.
• To assess treatment outcomes across different degrees of facial aging (mild, moderate, severe).

Main Methods:

• 62 patients were divided into three groups based on wrinkle severity.
• Three distinct treatment protocols involving amino acids, vitamins, hyaluronic acid, and carbon dioxide injections were administered.
• Efficacy was assessed using the Patient and Aesthetic Improvement Scale (PAIS) and Global Aesthetic Improvement Scale (GAIS).
• Statistical analysis included Wilcoxon's and Kolmogorov-Smirnov's tests using SPSS software.

Main Results:

• Statistically significant improvements (p<0.05) were observed in both PAIS and GAIS scores one week post-treatment and at the study's conclusion.
• No adverse side effects were reported by any of the participants.
• The treatment demonstrated effectiveness for mild, moderate, and severe facial aging.

Conclusions:

• The studied mesotherapy protocol, combining hyaluronic acid and carbon dioxide injections, provides statistically validated facial rejuvenation results.
• This treatment approach is effective for addressing various levels of facial aging.
• The safety profile of the treatment is favorable, with no adverse events noted.