Related Experiment Video
Updated: Feb 3, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
Ciliated HPV-Related Carcinoma: A Diagnostic Challenge on Frozen Section
Pooja Navale1, Eric M Genden2, Mary Beth Beasley3
1Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. pooja.navale@mountsinai.org.
Abstract:
Oropharyngeal squamous cell carcinomas associated with high risk HPV show a wide morphological spectrum, including papillary, adenosquamous, lymphoepithelioma-like and sarcomatoid. We report an interesting case of ciliated HPV-related carcinoma arising from tonsillar tissue in a 55-year-old man which was associated with HPV33. This rare variant has been described in only a handful of cases in the literature, and to our knowledge this is the first case specifically associated with HPV33. The presence of cilia is a potential diagnostic problem as it has been traditionally considered a feature of benignancy, and could pose a particular challenge on frozen section. The diagnostic challenges, differential diagnosis of this tumor and the association with HPV33 are discussed.
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