Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
Nursing Code of Ethics01:29

Nursing Code of Ethics

4.5K
The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
4.5K
System of Memory01:23

System of Memory

7.4K
Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...
7.4K
Working Memory01:24

Working Memory

883
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
883
Long-Term Memory01:18

Long-Term Memory

681
Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
681

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utilizing vmTracking to Improve the Accuracy of Multi-Animal Pose Estimation in Rodent Social Behavior Studies.

Journal of visualized experiments : JoVE·2025
Same author

A Case of Drug-Induced Lung Injury With Systemic Features Resembling DRESS Caused by Saiko-Ka-Ryukotsu-Borei-To and Goreisan.

Respirology case reports·2025
Same author

Recurrent diffuse alveolar haemorrhage in a patient receiving dialysis.

BMJ case reports·2025
Same author

Medical Thoracoscopy-assisted Thoracographic Fibrin Glue Sealing Method for Intractable Pneumothorax: A Case-based Proposal.

Internal medicine (Tokyo, Japan)·2025
Same author

Eventual resolution of pulmonary cavities following septic pulmonary embolism secondary to right-sided infective endocarditis.

BMJ case reports·2025
Same author

Effect of Hydrostatic Pressure on the <i>g</i> Tensor and Hyperfine Coupling Constants of the Nitroxide Radical Characterized by <i>Ab Initio</i> Calculations.

The journal of physical chemistry letters·2025

Related Experiment Video

Updated: Feb 3, 2026

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function
06:17

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

2.7K

The Hippocampal Ensemble Code for Spatial Navigation and Episodic Memory.

Susumu Takahashi1

  • 1Graduate School of Brain Science, Doshisha University, Kyoto, Japan. stakahas@mail.doshisha.ac.jp.

Advances in Neurobiology
|October 19, 2018
PubMed
Summary

The hippocampus, containing place cells, may encode not just location but also sequences of events, enabling mental time travel and future prediction. This suggests hippocampal neuronal ensembles are crucial for episodic memory and flexible spatial navigation.

Keywords:
Episodic memoryHippocampusPlace cellSpatial navigation

More Related Videos

Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing
10:32

Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing

Published on: January 11, 2013

17.0K
Assessing Spatial Learning and Memory in Small Squamate Reptiles
08:44

Assessing Spatial Learning and Memory in Small Squamate Reptiles

Published on: January 3, 2017

8.0K

Related Experiment Videos

Last Updated: Feb 3, 2026

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function
06:17

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

2.7K
Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing
10:32

Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing

Published on: January 11, 2013

17.0K
Assessing Spatial Learning and Memory in Small Squamate Reptiles
08:44

Assessing Spatial Learning and Memory in Small Squamate Reptiles

Published on: January 3, 2017

8.0K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Memory Research

Background:

  • Episodic memory allows re-experiencing past events in space and time.
  • Hippocampal damage, particularly to place cells, severely impairs episodic memory and spatial navigation.
  • Place cells in the hippocampus fire at specific locations, traditionally linked to spatial encoding.

Purpose of the Study:

  • To investigate if hippocampal place cell activity encodes more than just spatial information.
  • To explore the role of place cell ensemble activity in forming and recalling episodic memories.
  • To understand how the hippocampus facilitates flexible spatial navigation.

Main Methods:

  • Review of compelling investigations on hippocampal place cell firing patterns.
  • Analysis of the temporal flow and reactivation of place cell ensemble activity.
  • Examination of sequential activity patterns in hippocampal place cells.

Main Results:

  • Place cell firing patterns suggest encoding of future trajectories and events in space and time.
  • Hippocampal place cell activity can be reactivated in a temporally compressed manner during pauses.
  • Evidence supports the view that hippocampal neuronal ensembles contribute to episodic memory and spatial navigation.

Conclusions:

  • The hippocampus, through place cell ensembles, plays a critical role in episodic memory, including mental time travel.
  • Hippocampal place cell activity is fundamental for flexible spatial navigation and anticipating future situations.
  • Sequential activity and reactivation of place cells provide a neuronal basis for episodic memory and navigation.