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Programmed Electrical Stimulation in Mice
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Programmed longevity, youthspan, and juventology.

Valter D Longo1,2,3

  • 1University of Southern California, Los Angeles, California.

Aging Cell
|October 19, 2018
PubMed
Summary
This summary is machine-generated.

Periodic fasting activates longevity programs for cellular protection and rejuvenation, promoting a youthful, healthy state. This juventology approach complements traditional gerontology by focusing on maintaining youthful function.

Keywords:
JuventologyLongevityaginggerontologyhealthspanyouthspan

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Area of Science:

  • Aging and longevity research
  • Nutrient sensing and signal transduction
  • Cellular regeneration and rejuvenation

Background:

  • Conserved genes and pathways link nutrients, signaling, and aging.
  • Multiple nutrient-dependent "longevity programs" exist.
  • Dietary restriction can activate these programs.

Purpose of the Study:

  • To explore the link between nutrients, signaling pathways, and aging.
  • To understand how dietary interventions activate longevity programs.
  • To propose a "juventology" strategy for healthspan.

Main Methods:

  • Review of conserved genes and pathways regulating lifespan and healthspan.
  • Analysis of the effects of periodic fasting and dietary restriction.
  • Conceptual framework for juventology vs. gerontology.

Main Results:

  • Dietary restriction promotes entry into longevity programs.
  • These programs involve cellular protection, optimal function, and rejuvenation.
  • Rejuvenation is independent of the prior aging rate.
  • Longevity programs are selected based on nutrient availability.

Conclusions:

  • Periodic fasting and dietary restriction can induce rejuvenation and promote healthspan.
  • Juventology, focusing on longevity programs, offers a complementary approach to gerontology.
  • This strategy aims to maintain youthfulness, health, and function during extended life.