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Review and Preview01:10

Review and Preview

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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
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Review and Preview01:13

Review and Preview

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Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Group Therapy01:26

Group Therapy

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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

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Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Related Experiment Video

Updated: Feb 3, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Cardiac resynchronization therapy: a comprehensive review.

Jeremy Moskovitch1, Aleksandr Voskoboinik2,3,4

  • 1Alfred Heart Centre, Alfred Hospital, Melbourne, Australia.

Minerva Medica
|October 19, 2018
PubMed
Summary
This summary is machine-generated.

Cardiac resynchronization therapy (CRT) remains crucial for heart failure (HF) despite rising prevalence. This review explores current trials, indications, and emerging technologies for CRT in HF management.

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Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Management

Background:

  • Heart failure (HF) prevalence is increasing globally.
  • Medical treatments and implantable devices for HF are continuously advancing.
  • Cardiac resynchronization therapy (CRT) is an established HF treatment with evolving applications.

Purpose of the Study:

  • To provide a clinical perspective on cardiac resynchronization therapy (CRT) for heart failure (HF).
  • To review major clinical trials, current indications, and controversies surrounding CRT.
  • To discuss emerging aspects and competing technologies in CRT for HF.

Main Methods:

  • Literature review of major clinical trials.
  • Analysis of current clinical indications for CRT.
  • Discussion of controversies and emerging technologies in CRT.

Main Results:

  • Evidence for novel CRT indications is expanding.
  • Optimization of lead placement and device programming are critical.
  • New competing technologies are emerging in the CRT landscape.

Conclusions:

  • CRT remains a vital therapy for select heart failure patients.
  • Ongoing research and technological advancements are refining CRT applications.
  • A comprehensive understanding of CRT trials, indications, and future directions is essential for clinicians.