Related Experiment Video
Updated: Feb 3, 2026

Analysis of Oxidative Stress in Zebrafish Embryos
Published on: July 7, 2014
Leonurine ameliorates adriamycin-induced podocyte injury via suppression of oxidative stress
1a Department of Nephrology , the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University , Nanjing , China.
Abstract:
Leonurine, a major bioactive component from Herba Leonuri, shows therapeutic potential in several diseases, including diabetes, cardiovascular disease, bovine mastitis and depression. In kidney, it was reported that leonurine was performing a protective effect in both acute kidney injury and renal fibrosis mice models. The aim of this study is to investigate the effect of leonurine in podocyte injury. In the mice model of adriamycin (ADR) -induced nephropathy, the application of leonurine significantly prevented early kidney damage, macrophage infiltration and proteinuria. Meanwhile, leonurine suppressed ADR-induced podocyte injury and reactive oxygen species (ROS) production. Consistent to in vivo results, leonurine prevented ADR-induced podocyte injury and ROS production in cultured human podocytes. All these results suggested that leonurine might suppress ADR-induced podocyte injury via inhibiting oxidative stress. Leonurine might be a novel therapeutic drug for prevention of glomerular diseases.
More Related Videos
Related Concept Videos
Oxidation Numbers
Pyruvate Oxidation
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
Oxidation-Reduction Reactions
Responses to Salt Stress
Responses to Heat and Cold Stress
Oxidation of Alcohols
The process of oxidation in a chemical reaction is observed in any of the three forms:

