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Related Concept Videos

5-Number Summary01:04

5-Number Summary

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In a dataset, the 5-number summary includes the minimum data value, the data value of the first quartile, the median data value or data value of the second quartile, the data value of the third quartile, and the maximum data value. These 5 data values can be visualized as a box and whisker plot.
In a box plot, the minimum and maximum data values represent the lower and upper whiskers in the graph, and the median is designated as the center of the box in the chart. The first quartile and third...
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Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Schizophrenia01:17

Schizophrenia

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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

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Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
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Related Experiment Video

Updated: Feb 3, 2026

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
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Renaming schizophrenia: 5 × 5.

Sinan Guloksuz1, Jim van Os1

  • 1Department of Psychiatry and Neuropsychology,School for Mental Health and Neuroscience, Maastricht University Medical Centre,Maastricht,The Netherlands.

Epidemiology and Psychiatric Sciences
|October 19, 2018
PubMed
Summary
This summary is machine-generated.

Renaming schizophrenia to a psychosis spectrum disorder (PSD) offers significant benefits beyond semantics. This change supports a more holistic, patient-centered approach to mental health care.

Keywords:
DSM 5Diagnosis and classificationevidence-based psychiatrymental illness stigmaschizophrenia

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Area of Science:

  • Psychiatry and Mental Health Science
  • Clinical Psychology
  • Neuroscience

Background:

  • The term 'schizophrenia' faces challenges due to its historical context and limitations in capturing the full spectrum of psychotic experiences.
  • Current diagnostic models may overemphasize symptom reduction, potentially overlooking the trans-syndromal nature of mental health difficulties and patient needs.

Discussion:

  • This editorial advocates for a paradigm shift, proposing an umbrella category of psychosis spectrum disorder (PSD) to encompass various psychotic conditions.
  • The discussion explores the reasons, signals, challenges, promises, and steps involved in renaming 'schizophrenia' and adopting a spectrum approach.
  • It highlights the limitations of the current diagnosis-evidence-based-practice (EBP)-symptom-reduction model in mental health services.

Key Insights:

  • Adopting a psychosis spectrum disorder (PSD) framework offers a more inclusive and accurate classification of psychotic disorders.
  • Moving beyond 'schizophrenia' encourages a broader debate on psychiatric practice, emphasizing patient reality and relational care components.
  • Building resilience in social and existential domains is crucial for individual well-being when living with mental vulnerabilities.

Outlook:

  • Renaming 'schizophrenia' can catalyze the modernization of psychiatric science and services globally.
  • A spectrum approach to psychosis has the potential to improve patient outcomes and align mental health services with individual needs.
  • This conceptual revision is a crucial step towards a more adaptive and patient-centered future in mental healthcare.