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Updated: Feb 3, 2026
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A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction
Published on: August 27, 2019
17.6K
Rapamycin in ischemic stroke: Old drug, new tricks?
Gina Hadley1,2, Daniel J Beard1, Yvonne Couch1
11 Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Summary
Rapamycin, an mTOR inhibitor, shows promise in protecting brain cells after stroke by enhancing autophagy and benefiting the neurovascular unit. This could extend therapeutic windows and improve patient outcomes.
Area of Science:
- Neuroscience
- Pharmacology
- Neurology
Background:
- Stroke is a leading cause of neurological disability worldwide.
- Current effective stroke therapies (thrombolysis, thrombectomy) have narrow treatment windows.
- Endogenous neuroprotection involves mTOR signaling and autophagy.
Purpose of the Study:
- To review the potential of rapamycin as a neuroprotective therapy for stroke.
- To explore rapamycin's multimodal effects on the neurovascular unit.
Main Methods:
- Review of existing literature on rapamycin, mTOR pathways, autophagy, and stroke.
- Analysis of rapamycin's effects on neurons, blood-brain barrier, cerebral blood flow, and inflammation.
Main Results:
- Rapamycin, an mTOR inhibitor, is neuroprotective.
- It enhances neuronal autophagy and impacts other neurovascular unit cells.
- Rapamycin demonstrates potential benefits for blood-brain barrier integrity, cerebral blood flow, and inflammation reduction.
Conclusions:
- Rapamycin offers a potential multimodal therapeutic strategy for stroke.
- Repurposing rapamycin may extend treatment windows and improve functional outcomes post-stroke.
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