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Cryptococcus gattii Complex Infections in HIV-Infected Patients, Southeastern United States

Kaylee T Bruner, Carlos Franco-Paredes, Andrés F Henao-Martínez

    Emerging Infectious Diseases
    |October 19, 2018
    PubMed

    Insights

    Cryptococcus gattii infections are rare in HIV-positive patients. This study highlights three cases in the southeastern US, urging increased awareness for timely diagnosis and treatment of this fungal threat.

    Area of Science:

    • Mycology
    • Infectious Diseases
    • HIV/AIDS Research

    Background:

    • Cryptococcus gattii typically affects immunocompetent individuals, causing severe lung or central nervous system disease.
    • C. gattii infections are infrequently observed in patients with Human Immunodeficiency Virus (HIV).

    Observation:

    • This report details three cases of Cryptococcus gattii complex infections occurring in patients with HIV in the southeastern United States.
    • The presence of C. gattii in this specific patient population and geographic region is noteworthy.

    Findings:

    • The study identifies and documents HIV-associated Cryptococcus gattii infections.
    • These cases highlight a potential emerging trend or under-recognized occurrence of this fungal pathogen in immunocompromised hosts in the southeastern US.

    Implications:

    • The findings underscore the need for heightened clinical suspicion and awareness regarding C. gattii infections in HIV-infected patients.
    • Prompt and accurate diagnosis is essential for effective management and improved patient outcomes.
    • This emphasizes the importance of considering C. gattii in the differential diagnosis of fungal infections in immunocompromised individuals in this region.
    Keywords:
    CryptococcusCryptococcus gattiiCryptococcus gattii complexHIV-infected patientsHIV/AIDS and other retrovirusesPacific NorthwestUnited Statescase seriesfungiinfectionsmeningitis/encephalitissoutheastern United Statessouthwestern Georgiavirus

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