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Increased environmental temperature normalizes energy metabolism outputs between normal and Ames dwarf mice
Justin Darcy1,2,3, Samuel McFadden1, Yimin Fang1
1Division of Geriatric Research, Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62702, USA.
Aging
|October 19, 2018
Summary
Ames dwarf mice show improved energy metabolism and glucose homeostasis, potentially due to increased thermogenesis. Raising environmental temperature reduced brown adipose tissue activity and normalized respiration in these long-lived mice.
Area of Science:
- Endocrinology
- Metabolic Research
- Longevity Studies
Background:
- Ames dwarf mice exhibit hormone deficiencies and exceptional longevity.
- Increased respiration and lipid utilization are linked to mammalian longevity.
- Ames dwarf mice display hyperactive brown adipose tissue (BAT), possibly due to higher heat loss from their increased surface-to-mass ratio.
Purpose of the Study:
- To investigate if increased thermogenesis demand contributes to the metabolic and longevity phenotypes in Ames dwarf mice.
- To determine the effect of elevated environmental temperature on BAT activity and energy metabolism in Ames dwarf mice.
Main Methods:
- Ames dwarf mice and normal littermates were housed at an increased environmental temperature (eT).
- Brown adipose tissue (BAT) activity, oxygen consumption (VO2), respiratory quotient, and glucose homeostasis were measured.
Main Results:
- Increased eT diminished BAT activity in Ames dwarf mice.
- Elevated environmental temperature normalized VO2 and respiratory quotient between dwarf and normal mice.
- Increased eT partially normalized glucose homeostasis in Ames dwarf mice.
Conclusions:
- Increased demand for thermogenesis partially explains the enhanced energy metabolism in Ames dwarf mice.
- Environmental temperature influences BAT activity and metabolic parameters in Ames dwarf mice, suggesting a role for thermoregulation in their longevity phenotype.
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