Related Experiment Video
Updated: Feb 3, 2026
Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
Elevated neutrophil-to-lymphocyte ratio can predict procedural adverse events in patients with ST-elevation
Guilherme Pinheiro Machado1, Gustavo N Araujo2, Christian K Carpes1
1Department of Cardiology, School of Medicine, Federal University of Rio Grande do Sul.
Insights
High neutrophil-to-lymphocyte ratio (NLR) predicts complications in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI). A low NLR effectively predicts the absence of these adverse procedural outcomes.
Area of Science:
- Cardiology
- Inflammation markers
- Interventional cardiology
Background:
- Elevated neutrophil-to-lymphocyte ratio (NLR) is an indicator of inflammation.
- NLR is linked to adverse outcomes in ST-segment elevation myocardial infarction (STEMI).
Purpose of the Study:
- To assess the utility of NLR in predicting procedural adverse events.
- To evaluate NLR's role in patients undergoing primary percutaneous coronary intervention (PCI) for STEMI.
Main Methods:
- 664 STEMI patients undergoing primary PCI were analyzed.
- Patients were stratified into low and high NLR groups (high NLR ≥ 75th percentile, ≥9.45).
- Outcomes included procedural complications, in-hospital, 30-day major adverse cardiovascular events, and 1-year mortality.
Main Results:
- High NLR independently predicted in-hospital death, contrast-induced nephropathy, distal embolization, and no-reflow.
- Multivariate analysis showed NLR as a predictor for these adverse events (P<0.05).
- Low NLR demonstrated high negative predictive values for distal embolization (97.8%), no-reflow (96.9%), and procedural complications (92.1%).
Conclusions:
- High NLR is an independent predictor of adverse procedural outcomes in STEMI patients undergoing primary PCI.
- Low NLR is a valuable negative predictor for these complications.
- NLR serves as a potentially useful, inexpensive bedside tool for risk assessment.
Background:
Elevated neutrophil-to-lymphocyte ratio (NLR) is an indirect marker of inflammation, and is associated with adverse clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to investigate the usefulness of NLR to predict procedural adverse events is patients who underwent primary percutaneous coronary intervention (PCI).
Patients And Methods:
Consecutive patients with STEMI who underwent primary PCI were divided into low and high NLR, whereas high was defined as an NLR value above 75° percentile (≥9.45). The occurrence of procedural complications, in-hospital, and 30-day major adverse cardiovascular events and 1-year all-cause mortality were evaluated.
Results:
We included 664 patients with a mean age of 60.5 (±12.1) years and 66.3% were male. In multivariate analysis, NLR remained an independent predictor of in-hospital death [relative risk (RR)=1.03; 95% confidence interval (CI)=1.00-1.08; P=0.04], contrast-induced nephropathy (RR=2.35; 95% CI=1.11-4.71; P=0.02), distal embolization (RR=2.72; 95% CI=1.55-4.75; P<0.001), and no-reflow (RR=2.31; 95% CI=2.31-4.68; P=0.01). The area under the curve for distal embolization was 0.67, 0.64 for no-reflow and 0.62 for procedural complications. A low value of NLR had an excellent negative predictive value of 97.8, 96.9, and 92.1 for distal embolization, no-reflow, and procedural complications, respectively.
Conclusion:
High NLR is an independent predictor of distal embolization, no-reflow, and procedural complications in patients with STEMI who underwent primary PCI. A low NLR value has an excellent negative predictive value for these procedural outcomes. NLR may be a useful and inexpensive tool that may be used at bedside.
More Related Videos
18:11A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
Published on: December 28, 2012
05:52Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model
Published on: November 4, 2021
Related Concept Videos
03:12Freezing Point Depression and Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
01:20Elevation of Intermediate Points on Vertical Curves
01:03Nursing Interventions I: Taxonomy of Nursing Interventions
A nursing intervention is a treatment or action based on scientific concepts and knowledge from the nursing, behavioral, and physical sciences. Identifying and prioritizing nursing interventions based on the desired outcome...
01:29Nursing Interventions II: Selecting and Classifying the Nursing Interventions
02:27Predicting Molecular Geometry
01:23Poisson's Ratio