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Updated: Feb 3, 2026

EEG Mu Rhythm in Typical and Atypical Development
Published on: April 9, 2014
[The prognostic significance of biological rhythms assessment in depression]
1Sechenov First Moscow State Medical University, Moscow, Russia.
Aim:
To assess the prognostic significance of biological rhythms in depression on the example of the individual chronotype.
Material And Methods:
One hundred patients (women 68%), aged 18-77 years, mean age 48±16, were examined before and after 8 weeks of treatment. The Morningness-Eveningness Questionnaire (MEQ) was used. Treatment response (a decrease of 50% in total MADRS scores to the 8th week of treatment) and dynamics of depression severity (dMADRS; R) were assessed.
Results And Conclusion:
Evening chronotype was found to be associated with poor prognosis. TCAs and SSRIs were more effective in eveningness, other antidepressants - in morningness. MEQ changes during and after treatment may reflect the resynchronizing activity of antidepressants.
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