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Updated: Feb 3, 2026

Infant Auditory Processing and Event-related Brain Oscillations
Published on: July 1, 2015
[The evaluation of paroxysmal events in neonates and infants]
Eszter Nagy1, Nelli Farkas2, Katalin Hollódy1
1Pécsi Tudományegyetem, ÁOK-KK, Gyermekgyógyászati Klinika, Neurológiai Tanszék, Pécs.
Insights
Diagnosing infantile seizures by sight alone is difficult. Neonatologists and pediatric neurologists showed similar accuracy in identifying paroxysmal events, highlighting the need for video-EEG for accurate diagnosis.
Area of Science:
- Pediatric Neurology
- Neonatology
- Clinical Neuroscience
Background:
- Differentiating neonatal and infantile seizures based solely on visual inspection presents a significant diagnostic challenge, even for experienced specialists.
- Paroxysmal events in infants require careful evaluation to distinguish epileptic from non-epileptic causes.
Purpose of the Study:
- To investigate the diagnostic accuracy of various medical professionals in evaluating neonatal and infantile paroxysmal events based only on visual inspection.
- To determine if there are differences in the assessment of common infantile paroxysmal events among neonatologists, pediatric neurologists, and neurologists.
Main Methods:
- Video recordings of paroxysmal movements in 15 neonates and infants (2 days to 5 months old) were presented to 47 pediatric neurologists, 35 neonatologists/nurses, and 43 neurologists.
- Participants assessed events as epileptic or non-epileptic without access to patient history or electroencephalogram (EEG) results.
Main Results:
- Neonatologists and pediatric neurologists achieved similar correct diagnosis rates of 67% (824/1230).
- Significant diagnostic uncertainty was observed for subtle hand movements and rapid clonus, correctly identified by only one-third of participants.
- Neurologists' performance was slightly, but not significantly, different from that of pediatric neurologists.
Conclusions:
- Accurate diagnosis of neonatal and infantile paroxysmal events typically necessitates video-electroencephalogram (EEG) recordings.
- No significant difference was found between neonatologists and pediatric neurologists in their evaluation of infantile movement disorders.
- Established collaboration between pediatric neurologists and neurologists supports a unified approach to diagnosing these events.
Background And Purpose:
Differential diagnosis of neonatal and infantile seizures based only on inspection poses a challenge even for specialists. Aims - To investigate the evaluations of neonatal and infantile paroxysmal events based only on inspection. Research question - Is there any difference in the opinion of neonatologists, paediatric neurologists and neurologists about the assessment of common paroxysmal events in infancy?
Methods:
Video recordings about paroxysmal movements of 15 neonates or infants (aged 2 days- 5 months) were displayed for 47 paediatric neurologists, 35 neonatologists and nurses working in Neonatal or Perinatal Intensive Care Units and 43 neurologists. They had to decide without knowing the past medical history or EEG results whether events presented were epileptic or nonepileptic in nature.
Results:
Answers of neonatologists and paediatric neurologists were correct in 67% of cases (824/1230), no significant difference was found between their results. The largest uncertainty was in the judgement of discrete hand movements and very rapid clonus with epileptic origin, they were judged correctly by only one third of participants. The result of neurologists was only slightly, but not significantly different from that of paediatric neurologists.
Conclusion:
In most cases, the correct diagnosis of neonatal and infantile paroxysmal events requires video-EEG recording. No significant difference was revealed between the evaluation of neonatologists and paediatric neurologists about the differential diagnosis of movements. The ongoing cooperation of paediatric neurologists and neurologists going back to several decades facilitates the shaping of a common perspective.
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