Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Avian sarcoma virus 17 carries the jun oncogene.

Y Maki, T J Bos, C Davis

    Proceedings of the National Academy of Sciences of the United States of America
    |May 1, 1987
    PubMed
    Summary

    Avian sarcoma virus 17 (ASV 17) contains a unique oncogene, jun. This gene likely produces a gag-jun fusion protein responsible for cell transformation in ASV 17-infected cells.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Total selenium and selenomethionine in pharmaceutical yeast tablets: assessment of the state of the art of measurement capabilities through international intercomparison CCQM-P86.

    Analytical and bioanalytical chemistry·2007
    Same author

    Transverse beam spin asymmetries in forward-angle elastic electron-proton scattering.

    Physical review letters·2007
    Same author

    Emergency craniotomy targets.

    British journal of neurosurgery·2007
    Same author

    Radiology cases from the Royal Hospital for Sick Children, Glasgow: biloma as a complication of hepatic transection due to a handlebar injury.

    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie·2006
    Same author

    Measurement of the Ec.m. = 184 keV resonance strength in the 26gAl (p, gamma)27 Si reaction.

    Physical review letters·2006
    Same author

    Improving uptake of cervical cancer screening in women with prolonged history of non-attendance for screening: a randomized trial of enhanced invitation methods.

    Journal of medical screening·2006

    Area of Science:

    • Oncology
    • Virology
    • Molecular Biology

    Background:

    • Avian sarcoma virus 17 (ASV 17) possesses a replication-defective proviral genome.
    • The ASV 17 genome includes partial gag and env sequences flanking a novel oncogene.

    Purpose of the Study:

    • To characterize the newly identified oncogene, termed jun, within the ASV 17 genome.
    • To investigate the potential role of the jun gene and its protein product in cellular transformation.

    Main Methods:

    • Molecular cloning and characterization of the ASV 17 proviral genome.
    • Nucleic acid homology analysis to compare jun with known oncogenes.
    • Identification and characterization of viral proteins in transformed cells.

    Main Results:

    • The ASV 17 genome is approximately 3.5 kilobases (kb) and contains a 0.93 kb cell-derived jun gene.
    • The jun gene lacks conserved tyrosine-specific protein kinase domains and shows no significant homology to other oncogenes.
    • A 55-kilodalton (kDa) gag-jun fusion protein is identified as the likely transformation-specific protein in ASV 17-transformed cells.

    Conclusions:

    • The jun oncogene represents a novel genetic element contributing to ASV 17-mediated cell transformation.
    • The gag-jun fusion protein is the probable effector of cellular transformation induced by ASV 17.
    • ASV 17 provides a model for studying unique oncogenes and their mechanisms of action in viral carcinogenesis.

    Related Experiment Videos