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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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COPD: Pathogenesis and Clinical Features01:20

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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¹H NMR: Interpreting Distorted and Overlapping Signals01:02

¹H NMR: Interpreting Distorted and Overlapping Signals

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Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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Related Experiment Video

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Acupuncture in a Rat Model of Asthma
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Asthma-COPD overlap: identification and optimal treatment.

Borja G Cosío1,2, David Dacal3, Luis Pérez de Llano4

  • 1Department of Respiratory Medicine, Hospital Universitario Son Espases-IdISBa, Palma de Mallorca, Spain.

Therapeutic Advances in Respiratory Disease
|October 20, 2018
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Asthma-COPD overlap (ACO) diagnosis can be challenging. A new algorithm aids in identifying patients who may benefit from inhaled corticosteroids, improving asthma and COPD management.

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COPDasthmaasthma-COPD overlap

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Area of Science:

  • Pulmonology
  • Immunology

Background:

  • Asthma and COPD are common respiratory diseases that can occur together, termed asthma-COPD overlap (ACO).
  • The definition, prevalence, and prognosis of ACO vary significantly across studies.
  • The underlying biology of ACO is not well understood, but likely involves mixed inflammatory patterns.

Purpose of the Study:

  • To review and support a novel diagnostic algorithm for ACO proposed by the Spanish Respiratory Society (SEPAR).
  • To identify patients with ACO who could benefit from inhaled corticosteroids (ICSs) and potentially future biological therapies.
  • To provide a clinically applicable tool for diagnosing ACO.

Main Methods:

  • The SEPAR algorithm involves sequential evaluation: chronic airflow limitation in older smokers/ex-smokers with asthma, and either a significant bronchodilator test (PBT) or blood eosinophilia.
  • This review discusses the criteria and implications of the proposed diagnostic approach.
  • The algorithm aims to identify patients suitable for specific treatments.

Main Results:

  • The proposed algorithm can identify patients with ACO who may respond to inhaled corticosteroids (ICSs).
  • It offers a practical approach for clinical use in diagnosing ACO.
  • The algorithm's heterogeneity in grouping patients is a noted disadvantage.

Conclusions:

  • The SEPAR algorithm provides a structured method for diagnosing ACO, potentially guiding treatment decisions.
  • Personalized therapeutic objectives are recommended due to the heterogeneity within ACO.
  • Further research into biological therapies for ACO is suggested.