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Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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Related Experiment Video

Updated: Feb 3, 2026

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
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Alzheimer Disease.

John E Morley1, Susan A Farr2, Andrew D Nguyen1

  • 1Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard, M238, St Louis, MO 63104, USA.

Clinics in Geriatric Medicine
|October 20, 2018
PubMed
Summary
This summary is machine-generated.

Alzheimer disease involves amyloid-β and low progranulin, diagnosed via brain imaging. While current drugs offer limited help, cognitive stimulation therapy effectively treats moderate Alzheimer disease.

Keywords:
Amyloid-βBiomarkersCognitive stimulation therapyOlive oilProgranulinSAMP8

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Area of Science:

  • Neuroscience
  • Gerontology
  • Biochemistry

Background:

  • Alzheimer disease (AD) is characterized by elevated amyloid-beta (Aβ) levels and reduced progranulin (PGRN) levels.
  • Diagnostic challenges persist despite advancements in brain imaging techniques.
  • Current pharmacological interventions for AD exhibit limited therapeutic efficacy.

Purpose of the Study:

  • To review the underlying pathophysiology of Alzheimer disease.
  • To discuss the utility of various brain imaging modalities in AD diagnosis.
  • To evaluate the effectiveness of current treatments and explore alternative therapeutic strategies like cognitive stimulation therapy (CST).

Main Methods:

  • Literature review of Alzheimer disease pathophysiology, diagnostic imaging, and therapeutic interventions.
  • Analysis of studies on amyloid-beta and progranulin in AD.
  • Examination of clinical trial data for existing drugs and cognitive stimulation therapy.

Main Results:

  • Increased amyloid-beta and decreased progranulin are key pathological hallmarks of Alzheimer disease.
  • Brain imaging techniques provide valuable diagnostic support for Alzheimer disease.
  • Pharmacological treatments for Alzheimer disease have shown minimal clinical benefit, whereas cognitive stimulation therapy demonstrates significant efficacy in patients with moderate Alzheimer disease.

Conclusions:

  • Alzheimer disease pathogenesis is linked to amyloid-beta and progranulin dysregulation.
  • Advanced brain imaging aids in the diagnosis of Alzheimer disease.
  • Cognitive stimulation therapy represents a promising and effective non-pharmacological approach for managing moderate Alzheimer disease.