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Related Concept Videos

Lewis Acids and Bases02:33

Lewis Acids and Bases

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In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
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Lewis Acids and Bases02:16

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This lesson delves into Lewis acids and bases in the context of the octet rule for electron-deficient compounds. Here, the concept is discussed, emphasizing the group 13 elements like boron or aluminium. Since group 13 elements possess three valence electrons, they form trivalent compounds with a sextet of electrons and a vacant orbital for the central atom. Consequently, these electron-deficient compounds accept electrons from other species to complete their octet in a chemical reaction. They...
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Lewis Symbols and the Octet Rule02:36

Lewis Symbols and the Octet Rule

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Chemical bonds are complex interactions between two or more atoms or ions, which reduce the potential energy of the molecule. Gilbert N. Lewis developed a model called the Lewis model that simplified the depiction of chemical bond formation and provided straightforward explanations for the chemical bonds seen in most common compounds.
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Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Covalent Bonding and Lewis Structures02:46

Covalent Bonding and Lewis Structures

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Compared to ionic bonds, which results from the transfer of electrons between metallic and nonmetallic atoms, covalent bonds result from the mutual attraction of atoms for a “shared” pair of electrons.
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Lewis Structures of Molecular Compounds and Polyatomic Ions02:54

Lewis Structures of Molecular Compounds and Polyatomic Ions

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To draw Lewis structures for complicated molecules and molecular ions, it is helpful to follow a step-by-step procedure as outlined:
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Related Experiment Video

Updated: Feb 3, 2026

Using Retinal Imaging to Study Dementia
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Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

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Lewy Body Dementia.

Angela M Sanford1

  • 1Division of Geriatrics, Saint Louis University School of Medicine, 1402 South Grand Boulevard, M238, St Louis, MO 63104, USA.

Clinics in Geriatric Medicine
|October 20, 2018
PubMed
Summary
This summary is machine-generated.

Dementia with Lewy bodies (DLB) is a common neurodegenerative disease caused by alpha-synuclein protein aggregates. DLB is often misdiagnosed due to overlapping symptoms with other dementias, and current treatments focus on symptom management.

Keywords:
DementiaDementia with Lewy bodiesLewy body dementiaParkinson’s disease with dementiaSynucleinopathy

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Area of Science:

  • Neuroscience
  • Neurology
  • Pathology

Background:

  • Dementia with Lewy bodies (DLB) is the second most prevalent neurodegenerative dementia, following Alzheimer's disease.
  • DLB pathogenesis involves the aggregation of misfolded alpha-synuclein protein into Lewy bodies within the nervous system.
  • These protein deposits cause neuronal cell death, manifesting in characteristic clinical symptoms.

Purpose of the Study:

  • To elucidate the pathological mechanisms underlying Dementia with Lewy bodies.
  • To highlight the diagnostic challenges associated with DLB due to symptom overlap.
  • To review current therapeutic strategies for managing DLB symptoms.

Main Methods:

  • Review of existing literature on DLB pathophysiology and clinical presentation.
  • Analysis of diagnostic criteria and challenges in differentiating DLB from other dementia types.
  • Synthesis of information on current treatment approaches for symptom amelioration.

Main Results:

  • Alpha-synuclein aggregation in Lewy bodies is the core pathology of DLB.
  • Clinical presentation of DLB frequently overlaps with Alzheimer's disease and Parkinson's disease dementia, complicating diagnosis.
  • Effective disease-modifying treatments are lacking; current interventions manage symptoms.

Conclusions:

  • DLB represents a significant challenge in neurodegenerative dementia research and clinical practice.
  • Accurate and timely diagnosis of DLB is crucial for appropriate patient management.
  • Further research is needed to develop targeted therapies for DLB, addressing the underlying pathology.