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Sequencing through thick and thin: Historiographical and philosophical implications.

James W E Lowe1

  • 1Science, Technology and Innovation Studies, University of Edinburgh, Old Surgeons' Hall, High School Yards, Edinburgh, EH1 1LZ, UK.

Studies in History and Philosophy of Biological and Biomedical Sciences
|October 20, 2018
PubMed
Summary

DNA sequencing is often viewed as fast and automated. This research introduces "thick sequencing," a broader perspective encompassing practices that enable DNA sequence data use across communities, challenging the narrow "thin sequencing" view.

Keywords:
AnnotationAssemblyDNAGenomicsPhysical mappingSequencing

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Area of Science:

  • Genomics
  • Bioinformatics
  • History of Science

Background:

  • DNA sequencing is commonly characterized as 'big', 'fast', and 'automated' science.
  • This perception stems from a narrow focus on determining the order of DNA bases.

Observation:

  • Research on pig genome mapping and sequencing projects reveals a more complex reality.
  • The 'thin sequencing' perspective overlooks crucial practices that facilitate data dissemination and application.

Findings:

  • An alternative 'thick sequencing' perspective is proposed.
  • This broader view includes practices like minimum tile path generation and annotation.
  • Thick sequencing acknowledges the open-ended nature of sequencing projects and their broader impact.

Implications:

  • Rethinking DNA sequencing challenges historical analyses focused solely on automated processes.
  • Adopting a 'thick sequencing' view offers new historiographical and philosophical insights into genomics.
  • This perspective better reflects the collaborative and extended nature of scientific endeavors in genomics.