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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

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Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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¹H NMR Signal Multiplicity: Splitting Patterns01:13

¹H NMR Signal Multiplicity: Splitting Patterns

6.9K
When protons A and X are coupled, their nuclear spin energy levels are slightly modified. This is because the energy required to excite proton A to a spin state parallel to proton X is slightly different from the energy required for it to become anti-parallel to spin X. Consequently, there are two possible excitation frequencies for A (A1 and A2), depending on the spin state of X, and vice versa. The mutual nature of coupling implies that the difference between frequencies A1 and A2, indicated...
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Classifying Matter by Composition03:35

Classifying Matter by Composition

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Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures. 
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated. 
A mixture is composed of two or...
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Master Transcription Regulators02:23

Master Transcription Regulators

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Related Experiment Video

Updated: Feb 3, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Notch signalling patterns retinal composition by regulating atoh7 during post-embryonic growth.

Alicia Pérez Saturnino1,2, Katharina Lust1, Joachim Wittbrodt3

  • 1Centre for Organismal Studies, Heidelberg University, Heidelberg 69120, Germany.

Development (Cambridge, England)
|October 20, 2018
PubMed
Summary

The Notch-Atoh7 signaling pathway continuously patterns the teleost eye's ciliary marginal zone (CMZ). This axis ensures correct retinal cell proportions and de novo patterning for lifelong eye growth.

Keywords:
Atoh7Cell specificationMedakaNotchPost-embryonic growthRetinal progenitors

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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Last Updated: Feb 3, 2026

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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Area of Science:

  • Developmental biology
  • Neuroscience
  • Ophthalmology

Background:

  • The teleost eye grows throughout life, requiring continuous patterning of the ciliary marginal zone (CMZ).
  • Proper retinal cell-type composition is essential for visual function.
  • Signaling pathways regulating progenitor cell specification in the CMZ are not fully understood.

Purpose of the Study:

  • To investigate the role of the Notch-Atoh7 axis in patterning the continuously growing teleost retina.
  • To understand how progenitor cells in the CMZ give rise to diverse retinal cell types.

Main Methods:

  • Utilized the medaka fish (Oryzias latipes) model system.
  • Investigated the Notch-Atoh7 signaling axis in the CMZ.
  • Manipulated Notch signaling in Atoh7-expressing cells.

Main Results:

  • The Notch-Atoh7 axis continuously patterns the CMZ in medaka.
  • Juxtaposed progenitors with Notch or Atoh7 activity generate all retinal cell types.
  • Modulating Notch signaling in Atoh7 cells altered cell-type proportions.
  • Blocking Notch signaling initiated de novo retinal patterning and differentiation.

Conclusions:

  • The Notch-Atoh7 axis is crucial for continuous retinal patterning and cell-type specification in the growing teleost eye.
  • This axis couples de novo patterning with lineage specification in complementary progenitors.