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T-bet in Tfh cells: Now you see me, now you don't

Susan M Kaech1

  • 1Salk Institute for Biological Studies, La Jolla, CA skaech@salk.edu.

The Journal of Experimental Medicine
|October 20, 2018
PubMed

In this issue, Fang et al. (https://doi.org/10.1084/jem.20180927) report on a subset of T follicular helper (Tfh) cells that transiently expresses T-bet yet continues to produce IFN-γ at late stages of GC reactions following immunization. They find other genes uniquely expressed in this IFN-γ-producing Tfh subset, such as NKG2D, that can be used to better distinguish these functionally distinct Tfh cells.

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