Related Experiment Video
Updated: Feb 3, 2026

06:50
Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb
Published on: December 2, 2017
9.6K
Association between venous blood lactate levels and differences in quantitative capillary refill time
Yasufumi Oi1,2, Kosuke Sato1,2, Ayako Nogaki1,2
1Emergency Care Department Yokohama City University Hospital Yokohama Japan.
Acute Medicine & Surgery
|October 20, 2018
Summary
A new index, ΔAb, measured by quantitative capillary refill time, is a feasible, non-invasive tool for assessing high lactate levels in emergency settings. This method offers a rapid evaluation of circulatory status in critical care.
Area of Science:
- Emergency Medicine
- Critical Care
- Physiology
Background:
- Capillary refill time (CRT) is a standard clinical assessment for circulatory status in emergency settings.
- Previous research indicated a link between quantitative CRT and lactate levels in ICUs, but not in emergency departments.
- Limitations of traditional CRT necessitate the development of more precise quantitative measures.
Purpose of the Study:
- To identify a quantitative index of circulatory status, termed ΔAb, measurable with quantitative CRT.
- To evaluate the association between this novel index (ΔAb) and lactate levels in emergency department patients.
- To establish ΔAb as a clinically applicable tool for assessing circulatory status.
Main Methods:
- Prospective, single-center observational study conducted from November 2015 to July 2016.
- Inclusion of 139 patients with endogenous diseases.
- Measurement of quantitative capillary refill time, ΔAb (using a pulse oximeter), and lactate levels.
Main Results:
- ΔAb demonstrated an independent and significant association with high lactate levels.
- The odds ratio for high lactate levels associated with ΔAb was 0.16 (95% CI: 0.05-0.45).
Conclusions:
- ΔAb, derived from quantitative CRT, serves as a surrogate index for lactate levels, addressing CRT's limitations.
- ΔAb is a feasible, non-invasive, and rapid method for assessing patients with high lactate levels in emergency care.
- Further multicenter, longitudinal studies are recommended to validate these findings.
Related Concept Videos
Venous Return
12.3K
The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
12.3K
Capillary Beds
7.2K
Capillary beds are networks of tiny blood vessels that play a crucial role in the circulatory system. These beds are where the exchange of gases, nutrients, and waste products occurs between the blood and surrounding tissues. Each capillary bed consists of numerous capillaries, which are the smallest blood vessels in the body, typically only one cell-thick. This thinness allows for the efficient diffusion of substances.
Capillaries connect arterioles, small branches of arteries, to venules,...
Capillaries connect arterioles, small branches of arteries, to venules,...
7.2K
Capillary Exchange
11.3K
The cardiovascular system's chief role is to disseminate gases, nutrients, waste, and other substances to the body's cells. Small molecules like gases, lipids, and lipid-soluble substances directly diffuse through capillary wall endothelial cell membranes. Glucose, amino acids, and ions, including sodium, potassium, calcium, and chloride, use transporters for facilitated diffusion via membrane-specific channels. Glucose, ions, and bigger molecules may also pass through intercellular...
11.3K
Association Areas of the Cortex
9.4K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.4K
Associative Learning
1.3K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
Classical conditioning, also known...
1.3K
Electric Potential and Potential Difference
5.7K
Suppose a positive test charge moves away from a positive static charge, then the Coulomb force does positive work, and its electric potential energy decreases. The potential energy per unit charge is defined as the electric potential. The electric potential is independent of the test charge.
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...
5.7K

