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Updated: Feb 3, 2026

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials
Published on: June 25, 2018
Co-solvent polarity controlled self-assembly of tetraphenylethylene-buried amphiphile for size-regulated tumor
Jingsheng Huang1, Yun Chen1, Pengxiang Zhao2
1National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu, China.
Abstract:
We report that the co-solvent polarity can precisely control the TPE-buried amphiphile 1 to self-assemble into nanoparticles (NPs) in water with size range from ∼21-32 nm to 55-68 nm to 95-106 nm. Excepted for size, these TPE-buried amphiphile fabricated NPs hold identical physical properties such as spherical shape, surface charge, and luminescent properties, and moreover, after covalent capture of the acrylate hydrophilic heads, the resulting cross-linked NPs (cNPs I-III) own excellent in vivo stability, which thus would be an ideal platform for investigating the size effects on tumor accumulation and penetration.
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