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Updated: Feb 3, 2026

Intratracheal Administration of Dry Powder Formulation in Mice
Published on: July 25, 2020
POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy
Rita B Restani1, Rita F Pires2, Anna Tolmatcheva3
1LAQV, REQUIMTE Departamento de Química, Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa 2829-516 Caparica Portugal.
Abstract:
POxylated polyurea dendrimer (PUREG4OOx48)-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4OOx48 nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX-DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.
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