Related Experiment Video

Updated: Feb 3, 2026

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

2.4K

Loss of GINS2 inhibits cell proliferation and tumorigenesis in human gliomas

Yun-Long Shen1, He-Zhen Li1, Yan-Wei Hu2

  • 1Department of Neurosurgery, The Fifth Affiliated Hospital, South Medical University, Guangzhou, China.

CNS Neuroscience & Therapeutics
|October 20, 2018
PubMed
Abstract

Insights

GINS2 accelerates glioma growth, but suppressing it reduces tumor cell proliferation and tumorigenicity. GINS2 may be a therapeutic target and prognostic marker for glioma.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Glioma is a primary brain tumor with significant mortality.
  • Understanding the molecular mechanisms driving glioma development is crucial for effective treatment.

Purpose of the Study:

  • To investigate the expression of Ginsenoside Recognition Protein 2 (GINS2) in glioma.
  • To determine the role of GINS2 in glioma development and progression.

Main Methods:

  • Immunohistochemistry was used to assess GINS2 protein expression in 120 human glioma samples.
  • GINS2 expression was suppressed in U87 and U251 glioma cell lines using lentiviral vectors.
  • RNA sequencing, bioinformatics analysis, co-immunoprecipitation, and western blot were performed to identify downstream targets.

Main Results:

  • GINS2 expression was found to accelerate glioma cell growth, proliferation, and tumorigenicity.
  • Suppression of GINS2 led to decreased glioma cell proliferation and tumorigenicity.
  • GINS2 was shown to block the cell cycle by regulating downstream molecules including MCM2, ATM, and CHEK2.

Conclusions:

  • GINS2 plays a significant role in the occurrence and development of glioma.
  • GINS2 is a potential prognostic marker for glioma patients.
  • GINS2 represents a potential therapeutic target for glioma treatment.
Keywords:
GINS2cell cyclecell proliferationdigital gene expression profilinghuman gliomas

More Related Videos

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

8.3K
A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

17.5K

Related Concept Videos

Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.1K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.1K
Line Loss01:10

Line Loss

The different configurations of source-load connections include wye (star) and delta connections. The relationship between line and phase voltages and currents varies depending on the configuration. When the source is supplying power, it is transmitted through the wires to the load, and during this transmission, some power is absorbed by the wires, leading to line loss.
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
543
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.2K
Reducing Line Loss01:18

Reducing Line Loss

In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
390
Energy Losses in Transformers01:21

Energy Losses in Transformers

In an ideal transformer, it is assumed that there are no energy losses, and, hence, all the power at the primary winding is transferred to the secondary winding. However, in reality,  the transformers always have some energy losses, and, hence, the output power obtained at the secondary winding is less than the input power at the primary winding due to energy losses.
There are four main reasons for energy losses in transformers.
The first cause can be  the high resistance of the...
1.3K