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Updated: Feb 3, 2026

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
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Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

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miRNA and long non-coding RNA: molecular function and clinical value in breast and ovarian cancers

Konstantina Panoutsopoulou1, Margaritis Avgeris1, Andreas Scorilas1

  • 1a Department of Biochemistry and Molecular Biology, Faculty of Biology , National and Kapodistrian University of Athens , Athens , Greece.

Expert Review of Molecular Diagnostics
|October 20, 2018
PubMed
Abstract

Insights

Non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), play crucial roles in breast and ovarian cancers. These powerful gene regulators offer potential as biomarkers and therapeutic targets for personalized cancer medicine.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Tumor molecular hallmarks and novel markers are critical for personalized breast and ovarian cancer treatment.
  • Approximately 80% of the genome is transcribed into non-coding RNAs (ncRNAs), challenging the 'junk DNA' concept.
  • MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are key regulators of gene expression at multiple levels.

Purpose of the Study:

  • To review the involvement of miRNAs and lncRNAs in the molecular basis of breast and ovarian cancers.
  • To highlight the clinical utility of ncRNAs in improving disease management.
  • To discuss ncRNAs as potential molecular markers and therapeutic targets for precision medicine.

Main Methods:

  • Literature review of existing knowledge on ncRNAs in cancer research.
  • Analysis of high-throughput studies on genome transcription and ncRNA function.
  • Synthesis of information on miRNA and lncRNA deregulation in breast and ovarian tumors.

Main Results:

  • ncRNAs, particularly miRNAs and lncRNAs, are actively implicated in various aspects of cancer cell biology.
  • Aberrant expression of miRNAs and lncRNAs is observed in both breast and ovarian tumors.
  • These ncRNAs are central mediators of cancer cell phenotype.

Conclusions:

  • miRNAs and lncRNAs are significant regulators in breast and ovarian malignancies.
  • They hold promise as molecular markers for disease monitoring.
  • ncRNAs represent promising therapeutic targets for precision oncology in breast and ovarian cancers.
Keywords:
breast cancerlncRNAmicroRNAnon coding RNAovarian cancer

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