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Serotonin Subsystems Modulate Diverse and Opposite Behavioral Functions
Alvaro L Garcia-Garcia1, Mariano Soiza-Reilly2
1Department of Psychiatry, Division of Systems Neuroscience , Columbia University and the New York State Psychiatric Institute , 1051 Riverside Dr. Box 87 , New York , New York 10032 , United States.
Abstract:
Pioneering work showed that serotonin (5-HT) neurons have the unique capacity to engage in different and opposed aspects of motivated behaviors such as reward and punishment responses. These findings provided strong evidence about the functional heterogeneity of 5-HT neurons, and their possible engagement in multiple and behaviorally distinct neural subsystems. A recent study provides further compelling evidence supporting this notion, in which two ascending 5-HT circuits modulate opposed aspects of motivated behaviors.
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