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Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station INBEST

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Serotonin Subsystems Modulate Diverse and Opposite Behavioral Functions.

Alvaro L Garcia-Garcia¹, Mariano Soiza-Reilly²

¹Department of Psychiatry, Division of Systems Neuroscience , Columbia University and the New York State Psychiatric Institute , 1051 Riverside Dr. Box 87 , New York , New York 10032 , United States.

ACS Chemical Neuroscience

|October 20, 2018

Summary

This summary is machine-generated.

Serotonin (5-HT) neurons show functional heterogeneity, modulating opposing motivated behaviors like reward and punishment. A recent study reveals two distinct 5-HT circuits controlling these contrasting responses.

Keywords:

5-HT Amygdala Chemogenetics Frontal Cortex Optogenetics Punishment Reward

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Area of Science:

Neuroscience
Behavioral Science
Neurobiology

Background:

Pioneering research indicated serotonin (5-HT) neurons' role in diverse motivated behaviors.
Evidence suggested functional heterogeneity and involvement in multiple neural subsystems.

Purpose of the Study:

To provide further evidence for the functional heterogeneity of 5-HT neurons.
To investigate the role of specific ascending 5-HT circuits in modulating motivated behaviors.

Main Methods:

Utilized advanced neurobiological techniques to trace and analyze 5-HT circuits.
Employed behavioral assays to assess the impact of circuit activity on motivated responses.

Main Results:

Identified two distinct ascending serotonin (5-HT) pathways.
Demonstrated that these pathways differentially modulate opposing aspects of motivated behaviors, such as reward and punishment.

Conclusions:

Confirms the functional heterogeneity of serotonin (5-HT) neurons.
Highlights the role of specific 5-HT circuits in orchestrating complex, opposing motivated behaviors.