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Plasma Antioxidant Potential at Admission is Associated with Length of ICU Stay in Child with Sepsis: A Pilot Study

Abraham Ij Gajardo1, Bettina von Dessauer2, Víctor Molina2

  • 1a Program of Molecular and Clinical Pharmacology , Institute of Biomedical Sciences, Faculty of Medicine, University of Chile , Santiago , Chile.

Fetal and Pediatric Pathology
|October 20, 2018
PubMed

Insights

In septic children, higher ferric reducing ability of plasma (FRAP) levels at intensive care unit (ICU) admission correlate with longer ICU stays. This finding offers insights into predicting pediatric sepsis patient outcomes.

Area of Science:

  • Biochemistry
  • Pediatric Critical Care
  • Oxidative Stress Research

Background:

  • Sepsis is a life-threatening condition in children, often requiring intensive care.
  • Oxidative stress (OS) plays a role in sepsis pathophysiology.
  • Predicting length of stay in the intensive care unit (LSICU) is crucial for resource management and patient care.

Purpose of the Study:

  • To investigate the association between biomarkers of oxidative stress (OS) and the length of stay in intensive care units (LSICU) in pediatric sepsis patients.
  • To identify specific OS biomarkers that can predict LSICU.

Main Methods:

  • A study was conducted on 16 children admitted to the ICU for sepsis.
  • Clinical data and OS biomarkers were measured.
  • Linear correlation and multiple linear regression analyses were used to assess associations between OS biomarkers and LSICU.

Main Results:

  • LSICU in septic children averaged 7.13 ± 4.17 days.
  • LSICU showed a significant association with catalase activity (rho = 0.56, p=0.024) and ferric reducing ability of plasma (FRAP) (r = 0.73, p=0.001).
  • Ferric reducing ability of plasma (FRAP) at ICU admission was the only independent predictor of LSICU, with each 10 µmol/l increase in FRAP associated with a 0.21-day increase in LSICU.

Conclusions:

  • Ferric reducing ability of plasma (FRAP) level at ICU admission is independently associated with LSICU in pediatric sepsis patients.
  • FRAP may serve as a valuable predictive biomarker for the duration of intensive care in children with sepsis.
  • This study provides novel insights into the relationship between oxidative stress and clinical outcomes in pediatric sepsis.
Abstract

Keywords:
Oxidative stressbiomarkersintensive carelength of staypediatricssepsis

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