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Published on: April 2, 2018
Cobalt-Catalyzed Hydroboration of Alkenes, Aldehydes, and Ketones
Sem Raj Tamang1, Deepika Bedi1, Sara Shafiei-Haghighi1
1Department of Chemistry and Biochemistry , Texas Tech University , Lubbock , Texas 79409 , United States.
Abstract:
An operationally convenient and general method for hydroboration of alkenes, aldehydes, and ketones employing Co(acac)3 as a precatalyst is reported. The hydroboration of alkenes in the presence of HBpin, PPh3, and NaO tBu affords good to excellent yields with high Markovnikov selectivity with up to 97:3 branched/linear selectivity. Moreover, Co(acac)3 could be used effectively to hydroborate aldehydes and ketones in the absence of additives under mild reaction conditions. Inter- and intramolecular chemoselective reduction of the aldehyde group took place over the ketone functional group.
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