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Related Experiment Video

Updated: Feb 3, 2026

Generation of Human 3D Lung Tissue Cultures 3D-LTCs for Disease Modeling
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MARCKS and Lung Disease.

Mary K Sheats1, Qi Yin2, Shijing Fang2

  • 11 Department of Clinical Sciences and.

American Journal of Respiratory Cell and Molecular Biology
|October 20, 2018
PubMed
Summary
This summary is machine-generated.

Myristoylated alanine-rich C kinase substrate (MARCKS) protein regulates actin dynamics and is implicated in airway diseases. MARCKS-targeting peptide therapy shows promise for chronic bronchitis, lung cancer, and ARDS.

Keywords:
MARCKScancerinflammationlung disease

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Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Pulmonary Medicine

Background:

  • Myristoylated alanine-rich C kinase substrate (MARCKS) is a key protein involved in actin organization and cellular signaling.
  • MARCKS plays a role in cellular adhesion, migration, and exocytosis.
  • MARCKS is implicated in the pathophysiology of various lung diseases, including COPD, asthma, lung cancer, and ARDS.

Purpose of the Study:

  • To review the structure and function of MARCKS and its family proteins.
  • To discuss the role of MARCKS in lung disease pathogenesis.
  • To highlight therapeutic strategies targeting MARCKS for lung conditions.

Main Methods:

  • Literature review of MARCKS structure, function, and disease association.
  • Analysis of evidence linking MARCKS to lung diseases.
  • Overview of technological advancements in MARCKS-targeting therapies.

Main Results:

  • MARCKS regulates actin dynamics and bridges key signaling pathways.
  • MARCKS is increasingly recognized as a significant factor in airway disease development.
  • MARCKS-targeting peptide inhalation is being investigated in clinical trials.

Conclusions:

  • MARCKS is a crucial regulator of cellular processes relevant to lung health.
  • Targeting MARCKS presents a promising therapeutic avenue for lung diseases.
  • Ongoing clinical trials are evaluating the efficacy of MARCKS-targeting peptides for respiratory conditions.