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A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
Published on: July 25, 2017
The intimate relationship between gut microbiota and cancer immunotherapy
Arielle Elkrief1,2, Lisa Derosa3,4,5,6, Laurence Zitvogel3,4,5,6
1a Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM) , Montréal , Qc , Canada.
Abstract:
Immunotherapy is widely used to treat a large variety of malignancies and has revolutionized the therapeutic approach to cancer. Major efforts are ongoing to identify biomarkers that predict response to immunotherapy as well as new strategies to improve ICI efficacy and clinical outcomes. Studies have shown that the gut microbiome determines the extent to which ICIs may invigorate the anticancer immune response. Here, the authors review recent studies that have described the effects of the gut microbiota on the efficacy of CTLA-4 and PD-1 inhibitors and outline potential future clinical directions of these findings.
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