Hepatitis C is an Independent Risk Factor for Perioperative Complications and Nonroutine Discharge in Patients

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Luis Grau1, Erik Zachwieja1, Spencer H Summers1

  • 1Department of Orthopedic Surgery, University of Miami, Miami, FL.

Journal of Orthopaedic Trauma
|October 20, 2018
PubMed

Insights

Patients with noncirrhotic hepatitis C virus (HCV) infection undergoing hip fracture surgery face increased risks. This condition is an independent risk factor for perioperative complications and nonroutine discharge.

Area of Science:

  • Orthopedic Surgery
  • Hepatology
  • Epidemiology

Background:

  • Hip fractures are common, particularly in older adults.
  • Hepatitis C virus (HCV) infection affects a significant population and can impact surgical outcomes.
  • The specific impact of noncirrhotic HCV on outcomes after hip fracture surgery is not well-defined.

Purpose of the Study:

  • To evaluate the relationship between noncirrhotic hepatitis C virus (HCV) infection and perioperative complications.
  • To assess the association between noncirrhotic HCV infection and discharge status in hip fracture surgery patients.

Main Methods:

  • Retrospective epidemiological study using the National Hospital Discharge Survey.
  • International Classification of Diseases-9 codes used to identify hip fracture and surgical procedures.
  • Multivariable binary logistic regression analysis to determine independent risk factors.

Main Results:

  • A cohort of 5,377 patients with noncirrhotic HCV (HCV+) was compared to 4,712,159 patients without HCV (HCV-).
  • The HCV+ cohort experienced longer hospital stays, higher rates of nonroutine discharge, and more complications.
  • Multivariate analysis confirmed HCV+ as an independent risk factor for adverse outcomes.

Conclusions:

  • Noncirrhotic HCV infection is negatively associated with outcomes in hip fracture surgery.
  • Patients with HCV+ require careful management and preparation due to elevated risks.
  • Surgical teams should anticipate and mitigate increased perioperative complications and nonroutine discharge in HCV+ patients.
Abstract

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