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Protective effect of lycopene against chemical and natural toxins: A review

Narges Hedayati1, Mehri Bemani Naeini2, Alireza Nezami1

  • 1Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Biofactors (Oxford, England)
|October 20, 2018
PubMed

Insights

Lycopene, a potent antioxidant from fruits and vegetables, effectively reduces risks from natural and chemical toxins. This review highlights lycopene

Area of Science:

  • Toxicology
  • Nutritional Science
  • Biochemistry

Background:

  • Environmental, occupational, and therapeutic agents pose toxic risks.
  • These toxicants can disrupt organ function, gene expression, and homeostasis.
  • Lycopene is a powerful antioxidant found in fruits and vegetables.

Purpose of the Study:

  • To review the protective role of lycopene against natural and chemical toxicants.
  • To explore the mechanisms of lycopene as an antioxidant and its impact on inflammatory pathways.

Main Methods:

  • Literature review of recent studies on lycopene and toxicants.
  • Analysis of data on lycopene's antioxidative, antiapoptotic, radical scavenging, and chelating properties.

Main Results:

  • High lycopene intake is associated with reduced risk from mycotoxins, bacterial toxins, heavy metals, pesticides, and herbicides.
  • Lycopene exhibits significant antioxidative and radical scavenging activities.
  • Phytochemicals like lycopene play a role in modulating inflammatory pathways.

Conclusions:

  • Lycopene demonstrates efficacy in mitigating the adverse effects of various natural and chemical toxicants.
  • Further research into phytochemical mechanisms, including lycopene, is warranted for understanding their health benefits.
Keywords:
antioxidantscarotenoidheavy metalslycopenemycotoxins

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