Related Experiment Video
Updated: Feb 3, 2026

Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics
Published on: June 17, 2022
AMYPAD Diagnostic and Patient Management Study: Rationale and design
Giovanni B Frisoni1, Frederik Barkhof2, Daniele Altomare3
1Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland; Memory Clinic, University Hospital of Geneva, Geneva, Switzerland; Laboratory of Alzheimer's Neuroimaging and Epidemiology (LANE), Saint John of God Clinical Research Centre, Brescia, Italy.
This study investigates the clinical utility of amyloid-positron emission tomography (PET) in diagnosing Alzheimer's disease. It aims to provide real-world data for healthcare decisions and reimbursement strategies.
Area of Science:
- Neurology
- Radiology
- Health Economics
Background:
- Reimbursement for amyloid-positron emission tomography (PET) is limited by insufficient evidence regarding its clinical utility and cost-effectiveness.
- The Amyloid Imaging to Prevent Alzheimer's Disease-Diagnostic and Patient Management Study (AMYPAD-DPMS) aims to address this evidence gap.
Purpose of the Study:
- To evaluate the clinical utility and cost-effectiveness of early amyloid-PET imaging in the diagnostic workup of patients with cognitive decline.
- To provide real-world data to inform management decisions for physicians and healthcare payers.
Main Methods:
- Phase 4, multicenter, prospective, randomized controlled trial involving 900 patients.
- Patients with subjective cognitive decline, mild cognitive impairment, or dementia possibly due to Alzheimer's disease randomized into three arms: early amyloid-PET, delayed amyloid-PET, or physician-choice amyloid-PET.
- Primary endpoint: difference in very-high-confidence etiologic diagnosis between early and delayed amyloid-PET at 3 months.
Main Results:
- Primary endpoint data on diagnostic confidence and time to diagnosis are expected.
- Secondary endpoints will assess diagnostic/therapeutic management, health economics, patient-related outcomes, and image quantitation methods.
Conclusions:
- The AMYPAD-DPMS study is expected to generate crucial real-world data on the impact of amyloid-PET in clinical practice.
- Findings will inform reimbursement policies and guide patient management strategies for Alzheimer's disease diagnosis.
Related Concept Videos
Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Acute Pyelonephritis II: Diagnostic Studies and Management
Bioavailability Study Design: Healthy Subjects Versus Patients
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Design Example: Managing Concrete Workability

