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Bioactive monoterpene indole alkaloids from Nauclea officinalis
Yan-Ping Liu1, Qing-Long Liu2, Xiang-Lin Zhang1
1Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China; Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou 571158, PR China.
Bioorganic Chemistry
|October 20, 2018
Summary
Two new indole alkaloids from Nauclea officinalis, naucleaoffines A and B, show potent anti-inflammatory and anti-HIV activities. These compounds, along with six known alkaloids, offer potential for developing new therapeutic agents.
Area of Science:
- Natural Products Chemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Nauclea officinalis is a plant source of bioactive compounds.
- Indole alkaloids are a class of natural products with diverse biological activities.
Purpose of the Study:
- To isolate and characterize new indole alkaloids from Nauclea officinalis.
- To evaluate the anti-inflammatory and anti-HIV-1 activities of isolated compounds.
Main Methods:
- Isolation of alkaloids using chromatographic techniques.
- Structure elucidation of new compounds via spectroscopic methods (NMR, MS).
- In vitro assays for nitric oxide inhibition and anti-HIV-1 activity.
Main Results:
- Two new monoterpene indole alkaloids, naucleaoffines A (1) and B (2), were identified.
- Compounds 1-8 demonstrated significant inhibition of nitric oxide production in LPS-stimulated mouse macrophages.
- Compounds 1-8 exhibited potent anti-HIV-1 activity with EC50 values in the micromolar range.
Conclusions:
- Nauclea officinalis is a valuable source of indole alkaloids with significant anti-inflammatory and anti-HIV-1 properties.
- Naucleaoffines A and B represent novel chemical entities with therapeutic potential.
- The isolated alkaloids warrant further investigation as lead compounds for new drug development.
