Different ST2 Serum Concentrations in Asymptomatic and Symptomatic Carotid Artery Stenosis
Maurizio Taurino1, Raffaele Dito1, Gerardo Salerno2
1Department of Vascular Surgery, Sant'Andrea Hospital, University of Rome-"La Sapienza", Rome, Italy.
Background:
ST2 represents an interesting biomarker associated with the progression of atherosclerotic disease.
Methods:
This study aims to detect different ST2 serum concentrations, and intraplaque ST2 expression, in patients with symptomatic and asymptomatic carotid artery stenosis.
Results:
The analysis of ST2 expression in the atheromatous plaque did not show any significant difference between symptomatic and asymptomatic patients (39.61 ± 35.97 vs. 38.49 ± 35.26; P = ns). ST2 serum concentrations of asymptomatic and symptomatic patients were statistically different with a concentration of 11.04 ± 8.95 ng/mL and 13.91 ± 8.01 ng/mL, respectively (P = 0.037). We observed statistical difference in serum ST2 levels between asymptomatic and symptomatic patients for cerebrovascular acute disease. No differences have been obtained in intraplaque ST2 expression.
Conclusions:
Soluble serum ST2 levels can be a useful biomarker to identify patients at risk for cerebrovascular events.
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