When Small Molecules Are Like Real Estate: It's All about Location, Location, Location
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Michael DeRan1, Bridget K Wagner1
1Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA.
Cell Chemical Biology
|October 20, 2018
Abstract:
In this issue of Cell Chemical Biology, Park et al. (2018) demonstrate that targeting apoptazole, an Hsp70 inhibitor, to mitochondria induces apoptosis by a distinct mechanism of action different from unmodified apoptazole, which accumulates in the lysosome. These results highlight the power of subcellular localization in small-molecule selectivity.