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Updated: Feb 3, 2026

Introducing Point Mutations into Human Pluripotent Stem Cells Using Seamless Genome Editing
Published on: May 10, 2020
Stem Cells, Genome Editing, and the Path to Translational Medicine
Frank Soldner1, Rudolf Jaenisch2
1The Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
Abstract:
The derivation of human embryonic stem cells (hESCs) and the stunning discovery that somatic cells can be reprogrammed into human induced pluripotent stem cells (hiPSCs) holds the promise to revolutionize biomedical research and regenerative medicine. In this Review, we focus on disorders of the central nervous system and explore how advances in human pluripotent stem cells (hPSCs) coincide with evolutions in genome engineering and genomic technologies to provide realistic opportunities to tackle some of the most devastating complex disorders.
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