Related Experiment Video

Updated: Feb 3, 2026

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

3.3K

Clinical utility of susceptibility-weighted MR sequence for the evaluation of uterine sarcomas

Mayumi Takeuchi1, Kenji Matsuzaki2, Masafumi Harada1

  • 1Department of Radiology, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima 7708503, Japan.

Clinical Imaging
|October 20, 2018
PubMed
Abstract

Insights

Susceptibility-weighted MR sequences (SWS) accurately detect uterine sarcomas by identifying intra-tumoral hemorrhage. SWS offer superior diagnostic capability compared to traditional T1-weighted imaging for these rare gynecologic cancers.

Area of Science:

  • Radiology
  • Oncology
  • Gynecologic Imaging

Background:

  • Intra-tumoral hemorrhage on T1-weighted MRI is suggestive of uterine sarcomas, but prevalence varies.
  • Accurate diagnosis of uterine sarcomas is crucial for appropriate patient management.

Purpose of the Study:

  • To evaluate the diagnostic capability of susceptibility-weighted MR sequences (SWS) for uterine sarcomas.
  • To compare the effectiveness of SWS with T1-weighted imaging in identifying uterine sarcomas.

Main Methods:

  • Retrospective analysis of MR imaging in 10 surgically confirmed uterine sarcomas and 24 benign leiomyomas.
  • Evaluation for high intensity areas on T1-weighted images and signal voids on SWS (T2 star-weighted angiography: SWAN).

Main Results:

  • Signal voids on SWS were observed in 100% of sarcomas versus 4% of leiomyomas.
  • SWS demonstrated higher accuracy (97%), sensitivity (100%), and specificity (96%) compared to T1-weighted imaging (82%, 40%, 100%).

Conclusions:

  • SWS are highly effective in detecting intra-tumoral hemorrhage in uterine sarcomas.
  • SWS provide valuable diagnostic information for differentiating uterine sarcomas from benign leiomyomas.
Keywords:
Magnetic resonance imaging (MRI)SarcomaSusceptibility-weighted magnetic resonance sequenceT2 star-weighted angiography (SWAN)Uterus

More Related Videos

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining08:04

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

Published on: February 8, 2019

9.1K
Unbiased Deep Sequencing of RNA Viruses from Clinical Samples09:36

Unbiased Deep Sequencing of RNA Viruses from Clinical Samples

Published on: July 2, 2016

17.7K

Related Concept Videos

Uterine Tubes01:16

Uterine Tubes

The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
2.3K
Weighted Mean00:57

Weighted Mean

While taking the arithmetic, geometric, or harmonic mean of a sample data set, equal importance is assigned to all the data points. However, all the values may not always be equally important in some data sets. An intrinsic bias might make it more important to give more weightage to specific values over others.
For example, consider the number of goals scored in the matches of a tournament. While computing the average number of goals scored in the tournament, it may be more important to...
6.3K
Magnetic Susceptibility and Permeability01:31

Magnetic Susceptibility and Permeability

In linear magnetic materials, like paramagnets and diamagnets, magnetization is proportional to the magnetic field intensity. The constant of proportionality, a dimensionless number, is called magnetic susceptibility. The value of the susceptibility depends on the type of material.
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
2.4K
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
783
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
438
Atomic Weight01:25

Atomic Weight

Protons and neutrons have approximately the same mass, about 1.67 × 10-24 grams. Scientists arbitrarily define this amount of mass as one atomic mass unit (amu) or one Dalton. Electrons are much smaller in mass than protons, weighing only 9.11 × 10-28 grams, or about 1/1800 of an atomic mass unit. As a result, they do not contribute much to an element's overall atomic mass. This means that, when considering atomic mass, it is customary to ignore the mass of any electrons and...
13.0K