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Related Concept Videos

Acids, Bases and Neutralization Reactions03:26

Acids, Bases and Neutralization Reactions

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An acid-base reaction is one in which a hydrogen ion, H+, is transferred from one chemical species to another. Such reactions are of central importance to numerous natural and technological processes, ranging from the chemical transformations within cells or lakes and oceans to the industrial-scale production of fertilizers, pharmaceuticals, and other substances essential to the society.
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Lewis Acids and Bases02:33

Lewis Acids and Bases

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In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
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Lewis Acids and Bases02:16

Lewis Acids and Bases

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This lesson delves into Lewis acids and bases in the context of the octet rule for electron-deficient compounds. Here, the concept is discussed, emphasizing the group 13 elements like boron or aluminium. Since group 13 elements possess three valence electrons, they form trivalent compounds with a sextet of electrons and a vacant orbital for the central atom. Consequently, these electron-deficient compounds accept electrons from other species to complete their octet in a chemical reaction. They...
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Ions as Acids and Bases02:54

Ions as Acids and Bases

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Salts with Acidic Ions
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
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Bronsted-Lowry Acids and Bases02:58

Bronsted-Lowry Acids and Bases

105.0K
The acid-base reaction class has been studied for quite some time. In 1680, Robert Boyle reported traits of acid solutions that included their ability to dissolve many substances, to change the colors of certain natural dyes, and to lose these traits after coming in contact with alkali (base) solutions. In the eighteenth century, it was recognized that acids have a sour taste, react with limestone to liberate a gaseous substance (now known to be CO2), and interact with alkalis to form neutral...
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Acid-Base Titration Curves02:23

Acid-Base Titration Curves

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A titration curve is a plot of some solution property versus the amount of added titrant. For acid-base titrations, solution pH is a useful property to monitor because it varies predictably with the solution composition and, therefore, may be used to monitor the titration’s progress and detect its endpoint. Acid-base titration can be performed with a strong acid and a strong base, a strong acid and a weak base, or a strong base and a weak acid.
For a titration carried out for 25.00 mL of...
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Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
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Polylactic acid sealed polyelectrolyte complex microcontainers for controlled encapsulation and NIR-Laser based

Meiyu Gai1, Wenhao Li2, Johannes Frueh3

  • 1Max Plank Institute of Polymer Research, Ackermannweg 10, 55128, Mainz, Germany; School of Engineering and Materials Science, Queen Mary University of London, Mile End, Eng, 215, London, E1 4NS, United Kingdom; National Research Tomsk Polytechnic University, 634050, Tomsk, Russian Federation.

Colloids and Surfaces. B, Biointerfaces
|October 20, 2018
PubMed
Summary

This study introduces a rapid method for creating polylactic acid (PLA) coated microcontainers for drug delivery. These containers enable fast, laser-controlled release of hydrophilic cargo for various applications.

Keywords:
Controlled releaseNIR-LaserPolyelectrolyte complexPolylactic acidSmall hydrophilic molecules

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Assembly and Characterization of Polyelectrolyte Complex Micelles
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Assembly and Characterization of Polyelectrolyte Complex Micelles

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Area of Science:

  • Materials Science
  • Biotechnology
  • Drug Delivery

Background:

  • Surface-mediated drug delivery is crucial for medical and industrial applications, including controlling cell growth, preventing implant fouling, and anti-corrosion systems.
  • Existing methods using polyelectrolyte multilayers (PEM) for microcontainers (MCs) are time-consuming (days), while polylactic acid (PLA) MCs are hydrophobic and lack functionality.
  • There is a need for rapid fabrication of functional microcontainers for controlled substance release.

Purpose of the Study:

  • To develop a rapid fabrication method for polylactic acid (PLA) coated microcontainers (MCs).
  • To create functional biodegradable MCs capable of encapsulating hydrophilic cargo.
  • To enable controlled cargo release using laser stimulation.

Main Methods:

  • Fabrication of polylactic acid (PLA) coated microcontainers using synthetic and biopolymer-based polyelectrolyte complexes.
  • Encapsulation of small hydrophilic cargo within the fabricated MCs.
  • Demonstration of laser-controlled cargo release under submerged conditions.

Main Results:

  • Successfully fabricated functional PLA-coated biodegradable MCs in under one hour.
  • Demonstrated efficient encapsulation of small hydrophilic cargo.
  • Achieved precise, laser-controlled release of encapsulated cargo in aqueous environments.

Conclusions:

  • The developed method offers a rapid and versatile approach for producing functional microcontainers for controlled drug delivery.
  • PLA-coated biodegradable MCs present a promising platform for surface-mediated delivery applications.
  • Laser-triggered release provides a controllable mechanism for cargo delivery.