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Gray matter changes in panic disorder: A voxel-based meta-analysis and meta-analytic connectivity modeling
Yun Wu1, Yuan Zhong2, Zijuan Ma3
1School of Psychology, Nanjing Normal University, Nanjing, Jiangsu, China; Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China; Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, Jiangsu, China; Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, Jiangsu, China.
Psychiatry Research. Neuroimaging
|October 21, 2018
Summary
Magnetic resonance imaging studies reveal consistent gray matter changes in panic disorder (PD) brain regions. These findings highlight specific cortical areas as potential biomarkers for panic disorder.
Area of Science:
- Neuroimaging
- Psychiatry
- Neuroscience
Background:
- Magnetic resonance imaging (MRI) studies in panic disorder (PD) show inconsistent results regarding brain region damage.
- Identifying consistent structural changes is crucial for understanding PD pathophysiology.
Purpose of the Study:
- To identify consistent gray matter (GM) changes in PD using meta-analytic approaches.
- To characterize the functional and connectivity profiles of these affected brain regions.
Main Methods:
- Activation Likelihood Estimation (ALE) meta-analysis of eight whole-brain VBM studies.
- Meta-Analytic Connectivity Modeling (MACM) to analyze co-atrophy and co-activation patterns.
- Functional decoding to determine the functions of co-affected regions.
Main Results:
- Consistently reduced gray matter volume observed in bilateral dorsomedial prefrontal cortex (DMPFC), left dorsolateral prefrontal cortex (DLPFC), right insula, right superior temporal gyrus (STG), right middle temporal gyrus (MTG), and right superior orbital frontal cortex (OFC).
- Significant co-atrophy detected in STG, DMPFC, and OFC.
- Co-activation found between left DLPFC and bilateral DMPFC.
Conclusions:
- Decreased gray matter volume and associated co-atrophy/co-activation patterns in STG, OFC, DLPFC, and DMPFC suggest impaired higher cognitive functions in PD.
- Cortical regions showing these structural changes are important potential biomarkers for PD.
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