Study on the correlation of modified Blalock Taussig duct occlusion and platelet parameters in congenital heart...

Platelet parameters play an important role in thrombosis. This study investigates the role of platelet parameters in the occlusion of modified Blalock Taussig (BT).

To investigate the association between mean platelet volume (MPV), platelet distribution width (PDW) and BT conduit obstruction and to evaluate the role of MPV and PDW in BT conduit obstruction.

388 patients with modified BT shunt in the Pediatric Heart Center, Anzhen Hospital From January 1, 2008 to December 30, 2014 were divided into BT obstruction group (OBS) 11 cases and BT non-obstruction group (N-OBS) 377 cases according to whether the BT tube was occluded. The platelet count, mean platelet volume and platelet distribution width in the both groups were measured. The BT pipe occlusion related risk factors were analyzed.

There was no significant difference in PC value of OBS group [(221 ± 28.4) × 109/L] and that of N-OBS group [(198 ± 69.1) × 109/L). MPV [(15 ± 6.8) fL] and PDW (20 ± 6.4)% in OBS group were significantly higher than those in N-OBS group [(8 ± 3.2) fL, (15 ± 2.1)%] (P < 0.05). Logistic regression showed that BT occlusion was not related to the tube diameter and PC value (P > 0.05). Abnormal increases of MPV and PDW increased the risk of ductal occlusion [(OR = 2.1, 95%CI:1.47-2.49, P < 0.05), (OR = 2.4, 95%CI:1.71-3.87, P < 0.05)].

Improved BT postoperative occlusion are closely related to MPV and PDW. Increased MPV and PDW can increase the risk of postoperative BT occlusion.