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Fulminant mulch pneumonitis in a previously healthy child

I Maaloul1, S Ben Ameur1, I Chabchoub1

  • 1Department of pediatrics, Sfax Medical School, Hedi Chaker Hospital, Sfax, Tunisia.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|October 21, 2018
PubMed

Insights

Chronic granulomatous disease (CGD) can cause severe fungal pneumonia. A case study shows high-dose steroids and voriconazole successfully treated a boy with invasive aspergillus pneumonia, a leading cause of mortality in CGD.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Pulmonology

Background:

  • Chronic granulomatous disease (CGD) predisposes patients to recurrent infections, particularly invasive fungal pneumonias.
  • Aspergillus species infections are a major cause of mortality in CGD patients.
  • Fulminant fungal pneumonia presents a critical medical emergency in CGD.

Observation:

  • A rare case of late-onset CGD in an 11-year-old boy is presented.
  • The patient's CGD was revealed by a severe, rapidly progressing Aspergillus pneumonia.
  • This presentation highlights the potential for catastrophic fungal infections in undiagnosed CGD.

Findings:

  • Successful treatment was achieved using a combination of high-dose corticosteroids and voriconazole.
  • This therapeutic approach managed the acute, life-threatening fungal pneumonia effectively.
  • The case demonstrates a viable treatment strategy for invasive aspergillosis in CGD.

Implications:

  • Early diagnosis and prompt treatment are crucial for managing invasive fungal infections in CGD.
  • Combination therapy with steroids and antifungals can be life-saving in severe cases.
  • This case contributes to understanding treatment outcomes for invasive aspergillosis in pediatric CGD.
Keywords:
ChildChronic granulomatous diseaseFulminant mulch pneumonitisManagement

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