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Association between the full range of birth weight and childhood weight status: by gestational age
Li Cai1, Jun Tao2, Xiuhong Li1
1Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
Insights
Low birth weight increases childhood underweight risk, while high birth weight is linked to overweight and obesity. These associations were observed across various birth weights and gestational ages in children aged 6-18 years.
Area of Science:
- Pediatric Endocrinology
- Public Health Nutrition
- Developmental Pediatrics
Background:
- The link between high birth weight and childhood obesity is established.
- Few studies have explored birth weight's full spectrum and gestational age impact on childhood weight status.
Purpose of the Study:
- To investigate the association between the complete range of birth weight and childhood weight status.
- To stratify these relationships by gestational age groups.
Main Methods:
- Utilized data from a national survey of 65,347 children aged 6-18 years in China (2013).
- Employed objective measurements for child weight and height.
- Applied multivariable regression models to analyze associations between birth weight and childhood weight status.
Main Results:
- Low birth weight was associated with increased childhood underweight (OR 1.60).
- High birth weight correlated with increased overweight (OR 1.19) and obesity (OR 1.51), and decreased underweight (OR 0.57).
- These trends were significant in term and post-term infants, but not preterm, with associations weakening with age.
Conclusions:
- Low birth weight elevates the risk of childhood underweight, without impacting overweight or obesity.
- High birth weight increases the likelihood of childhood overweight and obesity while reducing underweight.
- Similar patterns were noted in term infants, highlighting the influence of birth weight on long-term weight status.
Background/Objectives:
The association between high birth weight and obesity is well known, but few studies have assessed the relationship across the full range of birth weight or in different gestational groups. We aimed to investigate the relationship between the full range of birth weight and childhood weight status stratified by gestational age.
Subjects/Methods:
A national survey of 65 347 children aged 6-18 years was conducted in China, 2013. Weight and height were objectively measured. Multivariable regression models were used to study the associations.
Results:
The prevalence of childhood underweight in the low, normal, and high birth weight groups was 10.39%, 6.87%, and 4.06%, respectively. Positive associations between birth weight (kg) and body mass index (BMI)/BMI z-scores were observed in the term, post-term, and overall groups, and this association was attenuated with age. Overall, low birth weight contributed to underweight [odds ratio (OR) 1.60, 95% confidence interval (CI) 1.23-2.10], but not to overweight/obesity. High birth weight was associated with overweight (OR 1.19, 95% CI 1.06-1.34) and obesity (OR 1.51, 95% CI 1.34-1.70), but reduced childhood underweight (OR 0.57, 95% CI 0.46-0.71) and normal weight. Similar trends were observed in the term, but not in the preterm group. High birth weight was positively related to obesity in the post-term subgroup (OR 2.06, 95% CI 1.03-4.11).
Conclusions:
Overall, low birth weight increased the risk of childhood underweight, but did not affect the risk of overweight or obesity. High birth weight increased childhood overweight and obesity, but decreased underweight. Similar trends were observed in the term group.
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